BME Faculty of Chemical Technology and Biotechnology
Thesis Projects 2020
Coordinator: Alfréd Kállay-Menyhárd (
Last update: 08.03.2020
Department of Applied Biotechnology and Food Science
Bioconversion of waste whey into high value added products: Fermentation of biodetergents
Supervisor: Áron Németh (Fermentation Pilot Plant Laboratory,
Whey is the major byproduct of dairy industry, which has great biotechnological potential, but is still mainly transported to wastewater treatments. Many bacteria produces different art of molecules (like glycopeptides etc.) having biodetergent activity, so we focuse of investigation of such whey based biodetergent fermentation.

Techniques: fermentation, steril work, shaking flask, microscopy, bioanalytics

Succinic acid fermentation
Supervisor: Áron Németh (Fermentation Pilot Plant Laboratory,
Succinic acid is a platform chemical, of which metabolsim has the advantage of carbon-dioxid fixation.

Techniques: fermentation, steril work, shaking flask, microscopy, bioanalytics

Department of Inorganic and Analytical Chemistry
Heteroatom modification of PAH’s for optoelectronic applications
Supervisor: László Nyulászi (Computation driven chemistry group,
Computational prediction of the electronic structure and optoelectronic properties of extended aromatic systems will be carried out in an international cooperation with experimental groups.

Techniques: Computational Chemistry

Preparation and application of functional nanostructures
Supervisor: Imre Miklós Szilágyi (
The project deals with the targeted preparation of functional nanomaterials with tailored properties for photocatalysis, gas sensing and nanofluids.

Techniques: XRD, SEM-EDX, TEM, Raman, FTIR, TG/DTA-MS, Photocatalysis, Gas sensing

Computations on low valent phosphorus compounds
Supervisor: Zoltán Benkő (
The aim of the project to perform computations on low-valent phosphorus species to understand their structural aspects, electronic structures and coordination properties, which may allow us to fine-tune the characteristics of these compounds for special applications (e.g. catalysis, optical electronics)

Techniques: Computational Chemistry

Pollution detection and monitoring in the Buda Thermal Karst System
Supervisor: Dénes Szieberth (
The aim of this project is to assess the vulnerability of the Molnár János cave, identify possible pollution routes by monitoring the chemistry of the drip waters entering the cave and finding correlation between the drip water chemistry, the dripping rates and the surface precipitation.

Techniques: classical and instrumental analytical techniques as well as advanced sampling and monitoring techniques

Department of Organic Chemistry and Technology
Synthesis and application of new asymmetric organocatalysts with cinchona skeleton
Supervisor: Jozsef Kupai (
The project deals with the synthesis of different cinchona alkaloid based organocatalysts. These catalysts will be applied in asymmetric Michael additions with pharmaceutical importance.

Techniques: HPLC, NMR, IR, preparative organic chemistry (extraction, distillation, recrystallization, thin layer and column chromatography).

Selective, heterogeneous catalytic hydrogenations in liquid phase
Supervisor: László Hegedűs (Heterogeneous Catalytic Reactions Research Group,
The project deals with the selective heterogeneous catalytic hydrogenation of compounds having catalyst poisoning character in liquid phase to obtain important and valuable pharmaceutical intermediates. In addition, poisoning of the precious metal catalysts during these hydrogenations will be examined to find relationships between the structure of substrate and the activity, as well as that of the catalyst.

Techniques: autoclaves, GC-MS, HPLC, NMR

Novel whole-cell- and enzyme-based immobilized biocatalysts for selective biotransformations
Supervisor: László Poppe (Bioorganic Chemistry Research Group,
The main focus of the research is the efficient application of novel immobilized biocatalysts for selective production of enantiomerically pure compounds with pharmaceutical relevance.

Techniques: bioinformatics, protein production and analysis, enzyme immobilization, UV, GC, HPLC, reactors, SEM, DLS, IR

Computer studies on enzymatic and chemical reactions
Supervisor: László Poppe (Bioorganic Chemistry Research Group,
The major aim of the research topic is to examine the function and selectivity of enzymes by computer methods. The mechanisms of ammonia-lyase-, aminomutase-, transaminase- and hydrolase-catalyzed reactions are primarily investigated at molecular level.

Techniques: bioinformatics, computation methods (homology modeling, ligand docking, QM / MM calculations)

Synthesis of heterocyclic organophosphorus compounds via multicomponent reactions
Supervisior: Erika Bálint (
The project deals with the synthesis of novel heterocyclic organophosphorus compounds by multicomponent reactions. The reactions will be accomplished mostly in a microwave reactor.

Techniques: Microwave reactor, continuous flow microwave reactor GC, HPLC, NMR, CombiFlash Rf Flash Chromatography System

Department of Physical Chemistry and Materials Science
Plastics for Outdoor Applications
Supervisor: Vida Ádám (Bay Zoltán Nonprofit Ltd.,
The main goal of this project is to discuss the influence of the primary environmental parameters, i.e., light, heat and the polymer structure and chemical make-up of the polymeric composites on the fundamental degradation processes.

Techniques: DTA, TG, 3D optical microscopy and SEM, polymer processing (internal mixer, compaction)

Spectroscopy of fluorescent chemosensors for the detection of biomolecules
Supervisor: Miklos Kubinyi (Spectroscopy Laboratory,
The objective of this project of the Faculty is the development of novel fluorescent indicators for the detection of biomolecules, like amino acids, nucleotides and neurotransmitters.

Techniques: Absorption and fluorescence spectroscopy, circular dichroism, NMR, MS, quantum chemistry

Production, characterization and application of cellulose nanocrystals
Supervisor: Emília Csiszár, Sebestyén Nagy (Laboratory of Plastics and Rubber Technologies,,
The project deals with the preparation of nanocellulose nanocomposites, produced by addition of different plasticizers and cross-linking agents to cellulose nanocrystals.

Techniques: ultra-sonication, particle size analysis by laser diffractometer, UV-Vis spectroscopy, haze-index test, WAXS, electron microscopy, mechanical tests, TGA, DMA, water sorption

Stabilization of polyolefins with natural antioxidants
Supervisor: Balázs Kirschweng, Béla Pukánszky (Laboratory of Plastics and Rubber Technologies,,
The aim of the project is to apply natural antioxidants as processing stabilizers for polyolefins and characterize the connection between their chemical structure and stabilizing efficiency during the processing of polymers.

Techniques: polymer processing (extrusion), MFR, DSC, FTIR and color measurement

Preparation and characterization of semiconductor sol-gel coatings on transparent substrates
Supervisors: Prof. Zoltán Hórvölgyi, Emőke Albert (Centre for Colloid Chemistry,,
The aim of the project is the development of different semiconductor sol-gel coatings on glass and polycarbonate substrates.

Techniques: UV-Vis spectroscopy, ellipsometric porosimetry, TEM and HRTEM, SEM and FESEM

Development of ab initio and density functional quantum chemical methods
Supervisor: Mihály Kállay (Spectroscopy Laboratory,
In this project we develop ab initio and density functional methods for the accurate theoretical modeling of large molecular systems

Techniques: quantum chemistry, ab initio correlation methods, density functional theory, programming

Modification of crystalline structure of semicrystalline polymers
Supervisor: Alfréd Kállay-Menyhárd (Laboratory of Plastics and Rubber Technologies,
The project deals with the targeted manipulation of crystalline structure in semicrystalline polymers. In addition general structure-property correlations are developed also, which can be used for prediction and designing of structures and properties.

Techniques: DSC, TGA, WAXS, microscopy, polymer processing (internal mixer, extruder, injection molding), mechanical and optical tests

Department of Chemical and Environmental Process Engineering
Application of biomass-based solvents for cross-coupling reactions
Supervisor: László T. Mika (Laboratory of Catalysis,
The thesis project is aimed to develop transition metal-catalyzed cross-coupling reactions (Heck, Sonogashira, Ullmann), which have significant importance in synthetic chemistry in biomass-based alternative reaction media.

Techniques: preparative chemistry, GC, GC-MS, NMR

Vapor-Liquid equilibrium study on bioliquids and conventional organic solvents
Supervisor: László T. Mika (Laboratory of Catalysis,
The thesis project is aimed to investigate and model the vapor-liquid equilibrium (VLE) between bioliquids and conventional organic solvents, reagents, and fuel additives.

Techniques: VLE measurement, GC, GC-MS, NMR, ChemCAD

Extraction of bioactives from agricultural waste / by-products
Supervisor: Erika Vági (Extraction Research Group,
The main objective of this project is to extract and concentrate different bioactive compounds from agricultural waste, side streams and by-products.

Techniques: solvent extraction, steam distillation, supercritical fluid extraction, in vitro antioxidant tests and spectrophotometric analysis.

High pressure phase equilibrium measurements and modelling
Supervisor: Edit Székely (High Pressure Research Group,
The main objective of this project is to determine the solubility of selected target compounds in pressurized carbon dioxide and expanded solvent mixtures in function of temperature and pressure.

Techniques: view cell measurement, mathematical model fitting.

X-ray fluorescence analysis
Supervisor: Iván Gresits (Laboratory Nuclear Spectroscopy
The main objective of this project is to analyze selected environmental or natural samples or catalysts to determine the concentrations of relevant elements from atomic number 15 to 94.

Techniques: X-ray fluorescence.

Investigation of factors influencing methanol content of fermented fruit pulp for pálinka production
Supervisor: Zsolt Csikor e-mail:

The purpose of the study is to investigate the effect of several factors (pH, T, yeast type etc.) on methanol and higher alcohol content of fermented fruit pulps, used in brandy (pálinka) production. The student will have to work at the laboratory of the National Food Chain Safety Office, so only diligent student will be accepted with some experience in analytical chemistry.